Lecture Notes

^{The
Hebrew University of Jerusalem}
^{The
Alexander Silberman Institute of Life Sciences}

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Lectures

2005-2006

2008-2009

2009-2010

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**2009-2010 Lectures** PLEASE NOTE: Due to copy rights limitations, lecture notes may only be viewed by providing your username (8 digits ID) and password (4 digits) or by using an OTP card, if you have one. (For OTP information click here)
Lecture No.	Date	Topic
1

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All the lectures are in pdf format (to reduce file size). If anyone needs the powerpoint (.ppt) file
please bring a disk-on-key to the lecture and I'll give you the files.

**2008-2009 Lectures** PLEASE NOTE: Due to copy rights limitations, lecture notes may only be viewed by providing your username (8 digits ID) and password (4 digits) or by using an OTP card, if you have one. (For OTP information click here)
Lecture No.	Date	Topic
1		Introduction
2		Protein-Protein Interaction
3		Biophysics
4		UV and CD
5		MS
6		AUC
7		Fluorescence
8		ITC and SPR
9		NMR
10		FTIR
11		Gel Filtration
12		Summary
13		Peptides
14		Protein Synthesis
15		Protein Folding
16		Kinetics
17		Folding mechanisms
18		p53 misfolding
19		Misfolding and disease

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**2005-2006**
Lecture No.	Date	Topic
1	5/3/06	Introduction
2	7/3/06, 12/3/06	Protein-protein interactions colour presentation (large file) black and white (smaller file, but still 5MB)
3	12/3/06	Thermodynamics of protein-protein interactions and ligand binding
4	19/3/06	Spectroscopic methods for protein analysis (UV, CD)
5	19/3/06	Protein analysis by mass-spectrometry
6	19/3/06, 26/3/06	Physical methods to study proteins: Analytical ultracentrifugation, analytical gel filtration, light scattering
Guest lecture 1	26/3/06	Analytical gel filtration: a guest lecture by Dr Mario Lebendiker
Guest lecture 2	2/4/06	Protein analysis using IR spectroscopy: a guest lecture by Eyal Arbely
7	23/4/06	Application of fluorescence spectroscopy to study proteins
Guest lecture 3	30/4/06, 7/5/06	NMR spectroscopy - application for proteins: a guest lecture by Dr. Debbie Shalev Part 1: introduction Part 2: Relaxation Part 3: Assignments Part 4: Interactions
8	14/5/06	Isothermal Titration Calorimetry (ITC), surface plasmon resonance (BIAcore)
9	14/5/06	Protein - Protein Interactions: Summary
10	14/5/06	The use of peptides to study protein-protein interactions
11	21/5/06	Chemical synthesis of proteins
12	21/5/06	Protein folding and stability
13	28/5/06	Kinetics: Introduction, kinetics of enzyme catalysis and ligand binding, introduction to pre-steady state kinetics, methods to study kinetics, kinetics of protein folding
14	28/5/06, 4/6/06	Mechanisms of protein folding
15	11/6/06	Protein misfolding and disease: Misfolding of p53 in cancer
16	11/6/06	Protein misfolding in disease - continued: other diseases, pharmacological chaperones
17	18/6/06	Summary

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