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The Alexander Silberman Institute of Life Sciences}

Required Reading

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Papers:

Protein-protein interactions:
 

1. Susan Jones and Janet M. Thornton (1996) Principles of protein-protein interactions, Proc. Natl. Acad. Sci. USA Vol. 93, pp. 13-20
2. Warren L DeLano (2002) Unraveling hot spots in binding interfaces: progress and challenges, Current Opinion in Structural Biology12:14-20
3. Irene M.A. Nooren and Janer M. Thornton (2003) Diversity of protein-protein intereactions, EMBO J 22 (14), 3486-3492
4. Michelle R.Arkin and James A.Wells  (2004) SMALL-MOLECULE INHIBITORS OF PROTEIN-PROTEIN INTERACTIONS: PROGRESSING TOWARDS THE DREAM, Nature Reviews Drug Discovery 3, 301-317

1. Gill, S.C. and P.H. von Hippel. (1989) Calculation of protein extinction coefficients from amino acid sequence data. Analytical Biochem. 182, 319-326 The original paper that describes how to calculate epsilon from amino acids sequences. Pdf is not available so you can look for it in the library if interested.

1. Lebowitz J. et al. (2002) Modern analytical ultracentrifugation in protein science: a review. Protein Science 11, 2067-2079

1. Wiseman T. et al. (1989) Rapid measurement of binding constants and heats of binding using a new titration calorimeter. Analytical biochemistry 179, 131-137 The original paper describing ITC. Pdf is not available so you can look for it in the library if interested.
2. Indyk and Fisher (1998), Theoretical aspects of isothermal titration calorimetry. Methods in Enzymology 295, 250-364 A good review that derives the equations behind ITC. Pdf is not available so you can look for it in the library if interested.
3. Pierce et al. (1999), Isothermal titration calorimetry of protein-protein interactions. Methods 19, 213-221 A good review describing how to prepare ITC experiments.

1. Dobson C. (2003) Protein folding and misfolding. Nature 426, 884-890 An excellent review about protein folding in the cell and what happend when proteins misfold

 

Textbooks:
 
 

Textbooks in  Harman Library	Companion Websites
Van Holde -Principles of physical biochemistry, 2006.
Cooper A. - Biophysical chemistry, 2004
Cantor and Schimmel - Biophysical chemistry, 1980
Fersht - Structure and mechanism in protein science, 1999
Branden and Tooze - Introduction to protein structure, 1999
Stryer - Biochemistry, 2007.	5th ed., 6th ed.

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