NCBI Conserved Domain Search
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RPS-BLAST 2.2.6 [Apr-09-2003] Query= local sequence: (630 letters) Database: cdd.v1.65 18,039 PSSMs; 5,506,404 total columns
gnl|CDD|25463 pfam00264, Tyrosinase, Common central domain of tyrosinase. This family also contains polyphenol oxidases and some hemocyanins. Binds two copper ions via two sets of three histidines. This family is related to pfam00372
 Domain Relatives
PSSMs producing significant alignments: Score
(bits)
E
value
 
gnl|CDD|25463 pfam00264, Tyrosinase, Common central domain of tyrosinase. Th... 386 8e-108


gnl|CDD|25463, pfam00264, Tyrosinase, Common central domain of tyrosinase. This family also contains polyphenol oxidases and some hemocyanins. Binds two copper ions via two sets of three histidines. This family is related to pfam00372.
             CD-Length = 327 residues, 100.0% aligned
             Score =  386 bits (993), Expect = 8e-108
Query:  106  TTEVPYFCCAP-KPDDMSKVPYYKFPSV-TKLRIRPPAHALDEAYIAKYNLAISRMKDLD  163
Sbjct:  1    GCDVRTNCCPPNIPDLSTKEPDFKFPSLDLAKRTRHPAHVVDTEYLAKYKGANGSMPQLA  60

Query:  164  KTQPDNPIGFKQQANIHCAYCNGGYSIDGK---VLQVHNSWLFFPFHRWYLYFYERILGS  220
Sbjct:  61   KISPYR--GFKQQAYYHCAYCNGAYLGSGFEDLELQVHESPLFFPWHRWYLLFYERILGK  118

Query:  221  LIDDPTFGLPFWNWDHPKGMRFPPMFDVPGTALYDERRGDQIHNGNGIDLGYFGDQV--E  278
Sbjct:  119  LIGDPTFALPYWNWDHPKGMRSPTLLSPEGSSLFDSWRNVCHRLPTLCNLTYEGPERRSR  178

Query:  279  TTQLQLMTNNLTLMYRQLVTNSPCPLMSLVDLTLFGSTVE-DAGTVENIP-HSPVHIWVG  336
Sbjct:  179  LPEDQDIENNLSLMYRQMVSNSPNALLFFGNPLEGGDKPDPGAGTIENEPVHNPVHIWTG  238

Query:  337  TRRGSVLPVGKISNGEDMGNFYSAGLDPLFYCHHSNVDRMWNEWKATGGK-RTDIQNKDW  395
Sbjct:  239  GNT-----------KEDMGSFYSAANDPIFYLHHSNVDRLWSIWKALGGKSRTDFPEADW  287

Query:  396  LNSEFFFYDENGNPFKVRVRDCLDTK-KMGYDYHATATPW  434
Sbjct:  288  LNGHFRFYDMNPFPPRVPNRDCFDTSDKLGYDYKDQLTPW  327