Your findings indicate that substance X abolishes the activity or activation of CDK2, but does not alter CDK2 levels.

12. Which of the following mechanisms may explain these results ?
(Choose between wrong and possible) [Get help from CDK Regulation.]

A. Substrate X prevents deactivating  phosphorylation of  CDK2.
B. Substrate X inhibits cyclin E binding to CDK2, and thus inhibits the activation of CDK2.
C. Substrate X inhibits p27 binding to CDK2-cyclin E complex, and thus inhibits the activation of CDK2.
D. Substrate X prevents activating  phosphorylation of  CDK2.
E. Substrate X blocks CDK2  substrate binding site and serves as an inhibitor of the activity of the kinase itself.

Choose the right answer/s and explain. 
Continue
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 


 

Did you have enough?
 
Please submit your answers to Tamar Makin by next week.

 
 
If you still have a little energy left, check Substance X putative site of action. 
You can also go to the beginning of this tutorial.

 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 

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